Neutrophil percentage to albumin ratio and advanced cardiovascular-kidney-metabolic syndrome in diabetes: a machine learning approach.

ABSTRACT:

Background

Diabetes mellitus (DM) has become an increasingly significant global health challenge, with rising complications and mortality rates. Patients with DM are at a higher risk for advanced Cardiovascular-kidney-metabolic (CKM) syndrome, underscoring the importance of early detection and precise prevention strategies. The neutrophil percentage to albumin ratio (NPAR), a composite biomarker, may be indicative of inflammatory dysregulation and nutritional status in patients with advanced CKM and DM. This study aims to explore the association between NPAR and advanced CKM in patients with diabetes.

Methods

Data were derived from six National Health and Nutrition Examination Survey (NHANES) cycles (1999-2020), including 9375 adults. Multivariable logistic regression analys

SUBMITTER: Zhuang Z 

PROVIDER: S-EPMC12720478 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature