Generational stability of environmentally induced epigenetic transgenerational inheritance of adult-onset disease over ten mammalian generations.

ABSTRACT: In traditional models of Drosophila flies and Caenorhabditis elegans worms, epigenetic transgenerational inheritance has persisted for hundreds of generations. Mammalian studies, however, have primarily investigated up to three or four generations. Environmental exposures to toxicants or other stressors have been linked to epigenetic transgenerational inheritance. Changes within the epigenome have the potential to alter gene expression and genetic processes, as well as potentially alter phenotypes and evolution in all organisms. In this study, an outcrossed mammalian colony of outbred rats was bred for 10 successive generations and assessed for epigenetic alterations and incidence of pathological abnormalities. The hypothesis tested was that epigenetic transgenerational inher

SUBMITTER: Korolenko AA 

PROVIDER: S-EPMC12720976 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature