Carbapenem resistance and antibacterial potential of the Libyan endemic plant Arbutus pavarii against metallo-β-lactamase-producing Gram-negative bacteria.

ABSTRACT: Background. Carbapenem-resistant Gram-negative bacteria (CR-GNB), particularly metallo-β-lactamase (MBL) producers, are WHO critical-priority pathogens. In Libya, laboratory-based data are scarce, and no study has assessed endemic medicinal plants as adjunctive options. Objectives. To generate baseline data on carbapenem resistance and MBL production among clinical Gram-negative pathogens in Misurata, Libya, and to preliminarily evaluate the antibacterial activity and phytochemical composition of Arbutus pavarii extracts. Methods. We conducted a cross-sectional study of 244 non-duplicate clinical isolates. Carbapenem susceptibility was determined by Kirby-Bauer disc diffusion; MBL production was confirmed by double-disc synergy and combined-disc tests. Ethanolic

SUBMITTER: Alwashaish MM 

PROVIDER: S-EPMC12720983 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature