PARP Activity Is Essential for Retinal Photoreceptor Survival in the Human Homologous Rho^I255del Mouse Model for Autosomal Dominant Retinitis Pigmentosa.

ABSTRACT: Retinitis Pigmentosa (RP) is a group of rare, inherited, neurodegenerative diseases of the retina that primarily affect rod photoreceptors. The initial loss of rods is followed by a secondary cone photoreceptor degeneration and eventually legal blindness. Despite several attempts, RP still remains essentially untreatable. In recent years, inhibition of poly (ADP-ribose) polymerase (PARP) has been proposed as a potential therapeutic strategy for autosomal-recessive RP, based on promising work in preclinical animal models. However, the effects of PARP inhibitors in autosomal-dominant RP are still largely unknown. Here, we employed a novel, human-homologous rhodopsin-mutant Rho^I255del/+ mouse model for autosomal dominant RP to assess the impact of different PARP inhibitors on the p

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12721004 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature