Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis.

ABSTRACT: Cytosolic translation activity is fine-tuned by environmental conditions primarily through signaling pathways that target translation initiation factors. Although mitochondria possess their own translation machinery, they lack an autonomous signaling network analogous to their cytosolic counterpart for regulating translation activity. Consequently, our understanding of how mitochondrial translation activity is adjusted under different metabolic environments remains very limited. Here, we report a noncanonical mechanism for regulating mitochondrial translation activity via metabolism-dependent changes in the mitochondrial ribosome (mitoribosome) in S. cerevisiae. These changes arise from a metabolism-modulated mitoribosome assembly pathway that regulates the composition and conformation of

SUBMITTER: Zheng F 

PROVIDER: S-EPMC12721022 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature