Pyrazolyl-functionalised Ag(i)-NHC complexes: synthesis, characterisation, antibacterial activity, and computational investigation.

ABSTRACT: In this study, five pyrazolyl-functionalised azolium salts with varying N-substituents (R-group) on the (benz)imidazolium rings, i.e. 3-(2-(3,5-dimethyl-1H-pyrazol-1-yl) ethyl)-1-R-1H-imidazole-3-ium chloride, where R = methyl (1a), ethyl (1b), benzyl (1c) and 3-(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)-1-R-1H-benzo[d]imidazole-3-ium chloride, where R = methyl (1d), ethyl (1e) were synthesised. Corresponding silver(i)-N-heterocyclic carbene complexes 2a-e were also synthesised from the deprotonation of the salts. All the compounds were characterised by spectroscopic and analytical techniques. In addition, all the salts and Ag(i) complexes were utilised as in vitro antibacterial agents against a broad spectrum of bacterial strains. Among the sy

SUBMITTER: Ruwizhi N 

PROVIDER: S-EPMC12721025 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature