Enhanced nuclear localization of small heterodimer partner in metabolic dysfunction-associated steatohepatitis.

ABSTRACT:

Background & aims

The nuclear factor small heterodimer partner (SHP) plays a dual function in maintaining bile acid (BA) homeostasis and exerting anti-inflammatory effects. While SHP might be associated with metabolic dysfunction-associated steatohepatitis (MASH), its role in patients remains unclear.

Methods

Liver tissue and serum samples were collected from 69 patients with MASH and 10 healthy controls. The subcellular distribution of SHP and related proteins in liver tissue were analyzed to correlate with MASH-associated pathological characteristics. In vitro studies were conducted to elucidate the underlying mechanisms and clinical relevance of SHP nuclear translocation in MASH.

Results

Compared with controls, patients with MASH demonstrated a higher nuclea

SUBMITTER: Chien SC 

PROVIDER: S-EPMC12721038 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature