Identification of hub genes in peripheral blood and construction of a diagnostic nomogram model in ulcerative colitis.

ABSTRACT: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that significantly impacts patients' quality of life and incurs substantial healthcare costs. Currently, the diagnosis of UC primarily relies on invasive examinations, highlighting the necessity for rapid, non-invasive, and low-cost diagnostic methods. This study aims to identify a biomarker that can diagnose and assess UC through bioinformatics analysis of databases. We identified 470 differentially expressed genes (DEGs) from the GSE169568 expression matrix, with 225 genes being up-regulated and 245 down-regulated. Functional analyses using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis demonstrated the enrichment of immune response-related processes. Weighted Gene Co-expression Netw

SUBMITTER: Li X 

PROVIDER: S-EPMC12721103 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature