The effects of nicotine on sleep in female C57BL/6J mice.

ABSTRACT: Sleep disturbances during nicotine withdrawal are well-documented and strongly linked to relapse. While previous studies, including our lab's work in male mice (Mathews & Stitzel, 2019), have characterized the effects of nicotine exposure and abstinence on sleep, potential sex differences remain unclear. Given that biological sex influences both nicotine addiction and sleep regulation, understanding its role in withdrawal-induced sleep disturbances is critical. This study examines the effects of nicotine exposure and abstinence on sleep in female C57BL/6 J mice using EEG/EMG recordings to assess sleep architecture and spectral power. Mice underwent chronic oral nicotine self-administration followed by abstinence, allowing for a detailed analysis of NREM and REM sleep metrics, sleep fragmen

SUBMITTER: Aki S 

PROVIDER: S-EPMC12721132 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature