The Hippo kinases MST1/2 integrate sterile and infectious signals to regulate macrophage cell death.

ABSTRACT: Mammalian STE20-like kinases MST1 and MST2 (mammalian STE20-like protein kinase-1/2) are the conserved Hippo kinases known for their importance in organ development and tumor suppression. Notably, humans and mice lacking these kinases have increased susceptibility to infection, indicating a role of MST1/2 in immunity. In macrophages that are critical immune cells in host defense, MST1/2 are proteolytically cleaved to coordinate different forms of programmed cell death, including apoptosis and pyroptosis. This cleavage event occurs when the innate immune sensors, inflammasomes, are activated by the bacterial pathogen, Legionella pneumophila, or damage-associated molecular patterns. In this report, we examine MST1/2 cleavage in macrophages under various inflammatory conditions and challenges

SUBMITTER: Quagliato SM 

PROVIDER: S-EPMC12721163 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature