Maternal antibodies shape infant immune response development in an epitope-specific manner.

ABSTRACT:

Background

The antibody repertoire in the blood encodes a comprehensive record of an individual's immunological encounters. Knowing the individuality of the repertoire would benefit in vaccinations, and also in personalising treatments. Formation of the immunoglobulin G (IgG) antibody repertoire starts before birth.

Methods

Here, we used a mimotope variation analysis (MVA) method to gain deeper insight into the repertoire of maternal antibodies actively transferred to newborns during pregnancy with the follow-up at 6 months.

Findings

Our study of 25 mothers and their neonates highlighted the strong correlation between maternal and neonatal antibody levels with comparable antigen-specificity shortly after birth. However, a noticeable blunting or interference in the ant

SUBMITTER: Sadam H 

PROVIDER: S-EPMC12721183 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature