Integrating spot-scanning proton arc therapy with functional avoidance strategies to reduce pulmonary toxicity.

ABSTRACT:

Background and purpose

Functional avoidance radiotherapy has emerged as a promising technique using functional imaging to minimize pulmonary toxicity by reducing doses to functional lung. This study aims to investigate the potential dose-volume advantages of a novel spot-scanning proton arc (SPArc) therapy for functional avoidance radiotherapy with four-dimensional computed tomography (4DCT)-based ventilation imaging.

Material and methods

Twenty-five patients from a prospective functional avoidance clinical trial treated with intensity-modulated photon radiotherapy were included. Robustly optimized intensity modulated proton therapy (IMPT) and SPArc plans were generated in RayStation. Functional lung contour was derived from the 4DCT-based ventilation imaging and utilized as

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12721199 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature