A KRAS^G12V-targeted bispecific T cell engager promotes immunity against colorectal solid tumor.

ABSTRACT: Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations have been detected at high rates in various tumor types, making them one of the most commonly mutated oncogenes. Limited relevant binding pockets have rendered these mutants undruggable for many decades, particularly the KRAS^G12V mutant. Recent advances in T cell receptor (TCR) profiling have provided a new strategy for overcoming this limitation by recognizing neoantigens presented by human lymphocyte antigen (HLA) and inducing T cell-mediated killing responses. Using the previously identified KRAS^G12V-targeting TCR, we engineered bispecific T cell engager receptors (TCERs) with high efficiency and specificity for the KRAS^G12V/HLA-A∗11:01 tetramer. Specifically, TCER01 and TCER02 effectively induc

SUBMITTER: Huynh N 

PROVIDER: S-EPMC12721267 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature