Inflammation contributes to trauma-induced coagulopathy by oxidation of multiple clotting factors.

ABSTRACT: Trauma-induced coagulopathy (TIC) induces anticoagulation and increases bleeding mortality. Inflammation and oxidative stress play an unknown role in TIC. We examined plasma from injured human trauma patients presenting to the Emergency Department compared to healthy controls to elucidate the contribution of inflammation and oxidative stress to anticoagulation during TIC. Trauma patients demonstrated coagulopathy by prolongation of clotting time assays and decreased thrombin generation in addition to increased pro-inflammatory cytokines and increased markers of oxidative stress. Clotting factors seven (FVII), ten (FX), and twelve (FXII) were oxidatively modified without quantitative changes, displaying decreased activity after trauma. Factor five (FV) was decreased in concentration and ret

SUBMITTER: Han CY 

PROVIDER: S-EPMC12721292 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature