An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn's Disease.

ABSTRACT:

Background & aims

Defining consequential differences in intestinal epithelial stem cells in healthy humans vs those with inflammatory bowel disease (Crohn's disease and ulcerative colitis) is essential for the development of much needed therapies to restore the epithelial barrier and maintain its fidelity.

Methods

We used single-cell transcriptomic and epigenomic approaches in matched patient tissues and organoids to investigate epithelial gene expression and function in children with no pathological diagnosis in the lower gastrointestinal tract and healthy adults compared with those with Crohn's disease.

Results

We identify an inflammatory secretory progenitor (ISP) cell state present almost exclusively in patients with Crohn's disease compared with healthy subjects.

SUBMITTER: Karakasheva TA 

PROVIDER: S-EPMC12721313 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature