TPR is required for circRNA, lncRNA and mRNA nuclear export.

ABSTRACT:

Background

Efficient RNA nuclear export is essential for proper cellular function and normal physiology, with defects in this process leading to pathological consequences. Our study aimed to investigate the role of translocated promoter region (TPR), nuclear basket protein, in orchestrating RNA transport in human cells as well as the function of TPR-mediated RNA nuclear export in cervical cancer cells.

Methods

RNA sequencing and bioinformatic analysis were applied to explore the effect of TPR on circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and mRNAs nuclear export and their corresponding sequence characteristic. Fluorescence in situ hybridization was employed to explore the role of TPR in RNA nuclear export. Immunofluorescence staining was used to study the role

SUBMITTER: Zhou M 

PROVIDER: S-EPMC12721318 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature