FLLL31 Induces Apoptosis via the FOXO4/BCL6 Axis to Inhibit Bladder Cancer Progression.

ABSTRACT: Bladder cancer represents one of the most common malignancies globally, posing a severe threat to human health. Through compound library screening, we identified tetramethylcurcumin (FLLL31), a diketone analog of curcumin, as exhibiting significant inhibitory effects on the malignant biological behaviors of bladder cancer cells. Although possessing diverse biological activities, the application of FLLL31 in bladder cancer has not been reported previously. To investigate the function and mechanism of FLLL31, we assessed its impact on the proliferation, migration, and invasion of T24 and 5637 cells using CCK-8, EdU, colony formation, and Transwell. The in vivo efficacy of FLLL31 was evaluated by intraperitoneal injection in BALB/c-nu mice bearing subcutaneous xenografts. Utilizing RNA-seq, q

SUBMITTER: Han Y 

PROVIDER: S-EPMC12721339 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature