Bidirectional and asymmetric smooth pursuit deficits in childhood hemispherectomy patients.

ABSTRACT: The neural circuitry engaged in supporting eye movements has been well characterized, but fundamental questions remain about the necessity and sufficiency of the individual hemispheric contributions. To gain a better understanding of the neural correlates of oculomotor control, we measured horizontal smooth pursuit tracking behavior in 14 patients following childhood hemispherectomy. Relative to developmentally typical age-matched controls, patients exhibited a bilateral and asymmetric pursuit deficit with reduced ipsilesional but elevated contralesional eye speeds, and asymmetric accompanying 'catch up' saccades. The atypical pursuit behavior could not be explained by a sensory deficit associated with their hemianopia, as patients adjusted their eye position to maintain visibility of the

SUBMITTER: Chroneos MZ 

PROVIDER: S-EPMC12721354 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature