Exploring the human small intestinal luminal microbiome via a newly developed ingestible sampling device.

ABSTRACT: Because accessing the small intestine is technically challenging, studies of the small intestinal microbiome are predominantly conducted in patients rather than in healthy individuals. Invasive clinical procedures, such as endoscopy or surgery, usually performed for therapeutic purposes, are typically required for sample collection. Although stomas offer a less invasive means for repeated sampling, their use remains restricted to patient populations. As a result, the small intestinal microbiome of healthy individuals remains largely understudied. This study evaluated a novel ingestible medical device for collecting luminal samples from the small intestine. A monocentric interventional trial (NCT05477069) was conducted on 15 healthy subjects. Metagenomics, metabolomics, and culturomics were

SUBMITTER: Tronel A 

PROVIDER: S-EPMC12721380 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature