Evaluation of glycine treatment for reducing alcohol craving and self-administration in individuals with alcohol use disorder: A human laboratory trial.

ABSTRACT:

Background

Alcohol use disorder (AUD) has limited treatment options and glycine receptors (GlyRs) in brain reward regions have emerged as tentative targets for pharmacotherapy. The rationale derives from studies showing that glycine, an endogenous GlyR agonist, alters dopamine (DA) transmission and reduces alcohol intake in rats. This study sought to translate these findings to individuals with AUD by examining whether glycine treatment reduces craving for alcohol and laboratory alcohol intake.

Methods

Individuals with AUD were randomized to oral glycine (0.12 g/kg) or placebo treatment for 5 days. Thereafter, 48 participants completed an alcohol challenge including priming for alcohol followed by self-administration of up to four drinks of 12 g alcohol. Alcohol craving and

SUBMITTER: Olsson Y 

PROVIDER: S-EPMC12721481 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature