High- and low-dose topiramate for the treatment of persons with alcohol use disorder who smoke cigarettes: A randomized control trial.

ABSTRACT:

Background

Tobacco use disorder (TUD) and alcohol use disorder (AUD) frequently co-occur and together are associated with worse prognoses. There are few options for treating both disorders concurrently. This study examined whether the antiepileptic drug topiramate would be effective for treating adults with both AUD and TUD.

Methods

Participants (n = 236) from three sites were randomly assigned to receive treatment adherence counseling and either placebo, low-dose topiramate (up to 125 mg/day), or high-dose topiramate (up to 250 mg/day) for up to 18 weeks, with a 5-week titration period. The primary outcomes were the mean percentage of heavy drinking days (PHDD) and the smoking continuous abstinence rate with biochemical verification during the last 4 weeks of treatment. Sec

SUBMITTER: Robinson JD 

PROVIDER: S-EPMC12721482 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature