Detection of Echinococcus granulosus sensu lato microRNAs in cystic echinococcosis patients: An exploratory study using quantitative PCR and digital PCR.

ABSTRACT:

Background

Cystic echinococcosis (CE) is a zoonosis caused by the larval stage of Echinococcus granulosus sensu lato (s.l.). The adult parasite typically resides in the intestine of canids, while the larval stage, a fluid-filled cyst, primarily resides in the liver and lungs of ungulates and humans. The diagnosis of abdominal CE in humans is mainly based on ultrasound (US) complemented by serology, but both techniques present limitations. Therefore, new diagnostic methods are needed. MicroRNAs (miRNAs) are potential suitable biomarkers for parasitic diseases, as well as for the diagnosis and cyst staging of CE. The objective of this study was to evaluate the presence of three E. granulosus s.l. miRNAs (egr-let-7-5p, egr-miR-10a-5p, and egr-miR-71-5p) in the serum of CE patients usi

SUBMITTER: Stocchero C 

PROVIDER: S-EPMC12721503 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature