Insecticide resistance levels, spatial distribution, and kdr mutations in the dengue vector Aedes albopictus of Hong Kong.

ABSTRACT: Aedes albopictus (Skuse), a primary dengue vector in Hong Kong, poses significant challenges to public health due to escalating insecticide resistance in Asia. To address this concern, we evaluated resistance profiles of five field-derived Ae. albopictus populations across Hong Kong using WHO insecticide susceptibility bioassays. Metabolic detoxification using synergists test with piperonyl butoxide (PBO) and target-site mutations referred to as knockdown resistance (kdr) in the voltage-gated sodium channel (VGSC) gene were characterized to elucidate resistance mechanisms. The results show that Ae albopictus populations in Hong Kong exhibited high resistance to commonly used pyrethroids (permethrin, deltamethrin) and the organochlorine dichlorodiphenyltrichloroethane (DDT), as well as emer

SUBMITTER: Han S 

PROVIDER: S-EPMC12721537 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature