Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice.

ABSTRACT: Pasteurella multocida is a Gram-negative bacterium that causes a range of distinct diseases in livestock animals. Different P. multocida diseases are associated with different capsule and lipopolysaccharide (LPS) types, but little else is known about what underpins this disease specificity. In this study, we utilised transposon-directed insertion site sequencing (TraDIS) to identify genes required for growth in rich media, and genes important for survival during systemic infections in BALB/c mice, for two diverse P. multocida strains; VP161 (capsule type A and LPS type L1) and M1404 (capsule type B and LPS type L2). Analysis of growth in heart infusion broth showed that both VP161 and M1404 shared 461 genes essential for growth in rich media, with 95% of these rich media-essential genes pr

SUBMITTER: Smallman TR 

PROVIDER: S-EPMC12721544 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature