Assessing the relative contributions of mosaic and regulatory developmental modes from single-cell trajectories.

ABSTRACT: Development is a complex process driven by coordinated cell proliferation, differentiation, and spatial organization. Classically, two ways to specify cell types during development have been hypothesized: the mosaic and regulative modes. In the mosaic mode, a particular cell isolated from the rest of the embryo will still give rise to progeny with the same fate as expected in normal development, relying on lineage-inherited factors. In contrast, in the regulative mode, the fate of a cell depends on its interactions with its environment and thus relies on space-dependent factors. While both modes often co-exist, their relative contributions remain poorly quantified at single-cell resolution. We present a novel approach to measure these contributions from single-cell data from C. elegans dev

SUBMITTER: Song S 

PROVIDER: S-EPMC12721551 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature