Urinary Analysis of <i>FGFR3</i> and <i>TERT</i> Gene Mutations Enhances Performance of Cxbladder Tests and Improves Patient Risk Stratification.

ABSTRACT:

Purpose

Cxbladder tests are urinary biomarker tests for detection of urothelial carcinoma. We developed enhanced Cxbladder tests that incorporate DNA analysis of 6 single nucleotide polymorphisms for the FGFR3 and TERT genes, in addition to the current 5 mRNA biomarkers and clinical risk factors.

Materials and methods

Two multicenter, prospective studies were undertaken in: (1) U.S. patients with gross hematuria aged ≥18 years and (2) Singaporean patients with gross hematuria or microhematuria aged >21 years. All patients provided a midstream urine sample and underwent cystoscopy. Samples were retrospectively analyzed using enhanced Cxbladder-Triage (risk stratifies patients), enhanced Cxbladder-Detect (risk stratifies patients and detects positive patients), a

SUBMITTER: Lotan Y 

PROVIDER: S-EPMC12721654 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature