Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina.

ABSTRACT: Parallel processing is a fundamental organizing principle in the nervous system and understanding how parallel neural circuits generate distinct outputs from common inputs is a key goal of neuroscience. In the mammalian retina, divergence of cone signals into multiple feedforward bipolar cell pathways forms the initial basis for parallel retinal circuits dedicated to specific visual functions. Here, we used patch-clamp electrophysiology, electron microscopy, and two-photon imaging of a fluorescent glutamate sensor to examine how kinetically distinct responses arise in transient versus sustained ON alpha retinal ganglion cells (ON-T and ON-S RGCs) of the mouse retina. We directly compared the visual response properties of these RGCs with their presynaptic bipolar cell partners, which we ide

SUBMITTER: Kuo SP 

PROVIDER: S-EPMC12721711 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature