Retrospective Analysis of Graft Loss Risk in Patients with BK Polyomavirus Associated Nephropathy in Relation to Rejection Status in a Multicentre Cohort with Regular Surveillance of BK Polyomavirus and Donor-Specific Antibody.

ABSTRACT:

Introduction

BK polyomavirus (BKPyV) in kidney transplant associated with adverse graft outcome. The aim of this study was to examine graft loss risk of BKPyV associated nephropathy (BKPyVAN) and BKPyV-DNAemia in relation with de novo donor-specific antibody (DSA) and rejection status.

Methods

Two hundred and forty patients from a multicentre cohort who had regular BKPyV and donor-DSA surveillance were retrospectively reviewed and stratified according to the presence of BKPyV-DNAemia and rejection.

Results

BKPyV-DNAemia did not associate with de novo DSA development (hazard ratio [HR] 1.15, 95% confidence interval [CI] 0.50-2.67, p = 0.74) but de novo DSA was more commonly observed in patients who developed rejection (BKV+/rejection- 4.3% (n = 2) vs. BKV+/rejection+ 5

SUBMITTER: Ma MK 

PROVIDER: S-EPMC12721717 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature