Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases.

ABSTRACT:

Background

Previous studies on the causal relationship or shared genetic basis between major depression disorder (MDD) and gastrointestinal (GI) diseases covered either a limited range and not comprehensive enough.

Methods

We used linkage disequilibrium score regression (LDSC) to estimate the heritability for nine traits and the genetic correlation (r _g ) between MDD and eight GI diseases, respectively. We further conducted a two-sample Mendelian randomization (MR) analysis to identify the causal relationship between MDD and eight GI diseases. Finally, based on the result of MR, we performed stratified LDSC (S-LDSC) to estimate the partitioned heritability and significantly enriched tissues, transcriptome-wide association study (TWAS) to define share

SUBMITTER: Sun F 

PROVIDER: S-EPMC12721742 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature