Impact of Hyperhomocysteinemia on Valve Calcification and Prognosis in Rheumatic Mitral Valve Surgery.

ABSTRACT:

Objective

Hyperhomocysteinemia is a risk factor for cardiovascular disease, but its impact on valve disease is lacking in research. This study was aimed at investigating the impact of hyperhomocysteinemia on rheumatic mitral valve calcification and prognosis in patients undergoing surgery.

Methods

This study included 672 patients with severe rheumatic mitral valve stenosis who underwent surgery between January 2016 and December 2022. Patients were stratified by preoperative homocysteine levels. Mitral valve pathology was assessed by echocardiography and coronary CTA, with all-cause mortality as the primary mid-term endpoint.

Results

Among this surgical cohort of 672 patients with severe rheumatic mitral stenosis, 208 (31.0%) patients were identified with hyperhomocyst

SUBMITTER: Jia S 

PROVIDER: S-EPMC12721752 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature