Sex-dependent hippocampal atrophy among people with methamphetamine-use experience.

ABSTRACT: As methamphetamine use rates continue to climb, understanding its relationship with physical, mental, and cognitive decline is critical. While memory difficulties are common, the underlying neurobiology of these deficits are not well understood. Preclinical work suggests that, at least among male subjects, methamphetamine exposure results in volume loss in the hippocampus, a critical brain region supporting memory outcomes. Human studies investigating the effect of methamphetamine use on hippocampal volume have been equivocal. These inconsistencies may relate to sex differences and varying degrees of use and abstinence in study samples. The current study evaluated hippocampal volume and associated hippocampal-dependent memory in a sex-balanced community sample of people with recent problem

SUBMITTER: Schwarb H 

PROVIDER: S-EPMC12721801 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature