Selective inhibition of long isoforms of phosphodiesterase 4D mitigates liver fibrosis in mouse models.

ABSTRACT: Chronic inflammation leads to tissue fibrosis, which can disrupt the function of the parenchyma of the organ and ultimately lead to organ failure. The most prevalent form of this occurs in chronic hepatitis, which leads to liver fibrosis and, ultimately, cirrhosis and hepatic failure. Although there is no specific treatment for fibrosis, the phosphodiesterase 4 (PDE4) competitive inhibitors have been shown to ameliorate fibrosis in rodent models. However, competitive inhibitors of PDE4 have shown significantly reduced effectiveness due to severe gastrointestinal side effects. The PDE4 family is composed of 4 genes (PDE4A-D), with each having up to 9 differentially spliced isoforms. Here, we report that PDE4D expression is specifically elevated during the hepatic fibrosis stage of liver dis

SUBMITTER: Kim J 

PROVIDER: S-EPMC12721886 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature