Targeted proteomics reveals immune protein patterns in serum from patients with calcific aortic stenosis.

ABSTRACT: Calcific aortic valve disease (CAVD) is a progressive condition with poor prognosis once symptomatic. The disease's progression is driven by a combination of mechanical stress, lipid infiltration, and immune responses, which involve both innate and adaptive immune systems. To explore the role of immune-related proteins in CAVD, we applied a targeted proteomic approach based on the proximity extension assay technique. Ten proteins were downregulated in patients with CAVD with respect to control subjects, indicating disrupted biological processes such as redox homeostasis, immune response, and cell motility. A protein-protein interaction network revealed connections between these proteins, with notable clusters associated with immune regulation and redox homeostasis. Further analysis identif

SUBMITTER: Mallia A 

PROVIDER: S-EPMC12722023 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature