Effect of the rs7858836 Single-Nucleotide Polymorphisms of the ASTN2 Gene on Pain-Related Phenotypes in Japanese Women Who Underwent Laparoscopic Gynecologic Surgery.

ABSTRACT:

Background

In our previous study, the minor T allele of the rs7858836 C/T single-nucleotide polymorphism (SNP) in the ASTN2 gene, which encodes astrotactin 2, was associated with reduced fentanyl requirements after laparoscopic-assisted colectomy and after mandibular osteotomy. In this study, we investigated the effects of this SNP on pain-related phenotypes in patients who underwent laparoscopic gynecologic surgery (LGS).

Methods

We studied 333 Japanese women, 21-69 years, who underwent LGS at Juntendo University Hospital between 2017 and 2019. We evaluated associations between SNP genotypes and postoperative pain-related phenotypes, including fentanyl requirements, rescue analgesic requirements, and the average pain scores on an 11-point Numeric Rating Scale (NRS) during t

SUBMITTER: Inoue R 

PROVIDER: S-EPMC12722107 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature