The Role of the Autoimmune Regulator Gene in the Control of MHC II Antigen-Processing and Presentation by Medullary Thymic Epithelial Cells.

ABSTRACT: The autoimmune regulator (AIRE) gene deficiency in humans causes the autoimmune polyglandular syndrome type 1 (APS-1). AIRE contributes to self-tolerance and prevents autoimmunity via the regulation of tissue-restricted antigen (TRA) expression in medullary thymic epithelial cells (mTECs). Using a murine Aire-deficient mTEC line (Aire^-/-), we previously reported that Aire regulates cell adhesion genes, affecting homotypic mTEC/mTEC and heterotypic mTEC/thymocyte interaction in vitro. Transcriptional analysis comparing Aire^WT with Aire^-/- mTECs indicates that Aire modulates antigen processing and presentation genes. Aire^-/- mTECs, but not Aire^WT, exhibited delayed expression of MHC II and CD74 molecules, suggesting that Aire influences

SUBMITTER: Monteleone-Cassiano AC 

PROVIDER: S-EPMC12722109 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature