Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD.

ABSTRACT: Autism and ADHD are characterised by atypical sensory responsivity, and this may be driven by alterations in the balance of cortical excitation to inhibition (E/I). Studies early in development are required to establish when sensory responsivity differences emerge and whether they predict later neurodevelopmental condition outcomes. We utilised data from a prospective longitudinal cohort of infants with and without a family history (FH) of autism and/or ADHD (N = 151; 55% male, 83% white). We extracted electroencephalography (EEG) metrics of E/I balance at 5, 10 and 14 months; the aperiodic exponent of the slope of the power spectrum ('1/f'). Models estimated latent growth curves of parent-reported hyper and hypo-responsivity between 10 - 36 months. Analyses tested associations between dev

SUBMITTER: Carter Leno V 

PROVIDER: S-EPMC12722238 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature