C7ORF41 Alleviates Ferroptosis Via the Keap1/Nrf2/HO-1 Axis in Endotoxin-Associated Acute Kidney Injury.

ABSTRACT: Endotoxin-associated acute kidney injury (EA-AKI) is a critical complication in intensive care units. Ferroptosis, an iron-dependent form of cell death characterized by lipid peroxidation, has been implicated in EA-AKI; however, its regulatory mechanisms remain unclear. Prior research links C7ORF41 to anti-inflammatory effects and cellular stress regulation. This study aimed to investigate the role of C7ORF41 in EA-AKI and its connection with ferroptosis. We used C7ORF41 knockout (KO) mice and wild-type (WT) mice to evaluate the impact of C7ORF41 on renal function and ferroptosis in an LPS-induced AKI model. Human renal cortical proximal tubular epithelial (HK-2) cells were transfected with C7ORF41 shRNA or control vector to study the role of C7ORF41 in ferroptosis in vitro. We measured se

SUBMITTER: Yu X 

PROVIDER: S-EPMC12722326 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature