The Kynurenine Pathway in Psoriasis: Mechanisms and Therapeutic Opportunities.

ABSTRACT: Psoriasis is a chronic inflammatory disease driven by genetic and environmental factors, with pathogenesis closely linked to metabolic reprogramming and immune microenvironment dysregulation. The kynurenine pathway (KP), as the principal route of tryptophan catabolism, plays a pivotal role in regulating immune tolerance, oxidative stress, and neuroinflammation, thereby serving as a "metabolic bridge" that links cutaneous lesions to systemic comorbidities in psoriasis. This review systematically examines the pathological mechanisms of KP in psoriasis. Imbalances in the activities of indoleamine 2,3-dioxygenase (IDO) and kynureninase (KYNU) in patients with psoriasis lead to a pro-inflammatory shift in KP. Moreover, downstream KP metabolites mediate oxidative damage, endothelial dysfunction,

SUBMITTER: Huang S 

PROVIDER: S-EPMC12722332 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature