Postoperative absence of residual intracranial tumor volume is associated with improved survival and intracranial disease control in non-small cell lung cancer brain metastases.

ABSTRACT:

Background

Brain metastases (BM) from non-small cell lung cancer (NSCLC) are associated with limited prognosis. Although surgical resection is part of multimodal management, the prognostic relevance of surgical intracranial tumor load reduction in the era of stereotactic radiotherapy and modern systemic therapies remains unclear.

Methods

This retrospective bicentric cohort study included 285 adults with histologically confirmed NSCLC who underwent BM resection. Pre- and postoperative MRI were used for volumetric assessment. Gross-total resection (GTR) was defined as the absence of measurable postoperative residual volume (RV). Outcomes were overall survival (OS) and intracranial progression-free survival (iPFS). Multivariable Cox regression models adjusted for age, preoperat

SUBMITTER: Bellomo J 

PROVIDER: S-EPMC12722344 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature