MiR-182-Mediated Dysregulation of Histidine Metabolism Compromises T Cell Immunity in Sepsis.

ABSTRACT: MicroRNA-182 (miR-182) exhibits immunomodulatory effects in regulating inflammatory responses to bacterial infection. However, the involvement of miR-182 in regulating T-cell immune function and differentiation in sepsis remains unknown. This study investigated the role of miR-182 in regulating T cell immune function and its mechanism in sepsis-induced immunosuppression. Using the cecum ligation and puncture model to mimic experimental sepsis, we found a significant reduction in splenic lymphocyte numbers and dysregulated T cell differentiation in septic mice. miR-182 expression was elevated in septic mice. Its knockout improved T cell immune function, ameliorated organ damage and improved survival rates in septic mice. Metabolomic and proteomic profiling revealed that histidine catabolism

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12722347 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature