Inhibition of Macrophage Activation by Minocycline Attenuates CCI-Induced Neuropathic Pain.

ABSTRACT: Neuropathic pain is characterized by a high prevalence and associated with a variety of disorders of the peripheral and central nervous systems. It remains a major challenge for clinical management due to lack effective treatments. Our previous studies have demonstrated that nerve injury-induced neuroinflammation plays a critical role in regulating the development and maintenance of neuropathic pain. In the present study, we found that chronic constriction injury (CCI) led to a significant increase in the number of macrophages at the site of injured nerves. To elucidate the role of macrophage activation in CCI-induced neuropathic pain, we employed chemical agents, including clodronate liposomes, which is known for their ability to deplete macrophages, and minocycline, an inhibitor of macro

SUBMITTER: Ji YZ 

PROVIDER: S-EPMC12722355 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature