Artificial intelligence-enabled analysis of handheld single-lead electrocardiograms to predict incident atrial fibrillation: an analysis of the VITAL-AF randomized trial.

ABSTRACT: Whether artificial intelligence (AI) analysis of single-lead ECG (1 L ECG) can predict incident AF is unknown. In the VITAL-AF trial (ClinicalTrials.gov NCT03515057, registered 2/24/2021) of primary care patients aged ≥65 years undergoing handheld 1 L ECG screening, we tested three AI approaches to incident AF prediction, and compared the best model to the CHARGE-AF risk score. In a test set of 4,221 individuals, a published AI model trained using single standard ECG leads ("1 L ECG-AI") provided similar 2-year AF discrimination to models trained with VITAL-AF data. In the full VITAL-AF sample of 15,694 individuals without prevalent AF (2-year incident AF 3.1%), 1 L ECG-AI with age/sex (1 L ECG-AI AS) had comparable discrimination (area under the receiver operating characteristic curve [AU

SUBMITTER: Khurshid S 

PROVIDER: S-EPMC12722369 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature