STAT3 Signaling Mediates Agomelatine Restoration of Prefrontal Cortex Synaptic Plasticity in Chronic Social Defeat Stress Mice.

ABSTRACT: Major depressive disorder (MDD) is a major public health issue worldwide. It not only causes an increased socio-economic burden, but also negatively affects personal lives. It has been shown that depression leads to impairments in synaptic plasticity, such as impaired long-term potentiation (LTP) in the prefrontal cortex (PFC). A recent study reported that administration of agomelatine, a melatonin receptor agonist and 5-hydroxytryptamine (5-HT) 2C antagonist, which may be involved in synaptic functions, for 1 week has a rapid antidepressive effect. Moreover, the mechanism of Glycogen synthase kinase 3β (GSK3β), regulated by signal transducer and activator of transcription 3 (STAT3), may play an important role in the synapse-related pathological mechanisms of depression. Hence, we used chr

SUBMITTER: Lee CW 

PROVIDER: S-EPMC12722381 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature