Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.

ABSTRACT: Acute lung injury (ALI) is a critical condition characterized by uncontrolled inflammation, respiratory insufficiency, and tissue damage, often triggered by pneumonia or sepsis. Aberrant activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome and subsequent pyroptosis are key drivers of ALI pathogenesis. Palmatine (PAL), a naturally derived isoquinoline alkaloid with diverse pharmacological effects, was investigated for the therapeutic potential against lipopolysaccharide (LPS)-induced ALI in this study, focusing on NLRP3 inflammasome, pyroptosis, and metabolic regulation. Our findings showed that PAL significantly suppressed NLRP3 inflammasome activation and pyroptosis in LPS/adenosine triphosphate (ATP)-stimulated THP-1 macrophages and inhibit

SUBMITTER: Ning P 

PROVIDER: S-EPMC12722388 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature