SAA1 Promotes Ulcerative Colitis and Activating Colonic TLR4/NF-κB/NLRP3 Signaling Pathway.

ABSTRACT: Ulcerative colitis (UC) is a chronic inflammatory disease of the colorectal characterized by dysregulation of cytokine production resulting from abnormal innate and adaptive immune responses, which promote inflammation. Serum amyloid A (SAA) proteins are key components of the acute inflammatory response and have been found to be positively associated with UC disease activity in clinical studies. In this study, we employed a well-established DSS-induced UC model and conducted non-targeted proteomic detection to identify significantly differentially expressed proteins and related biological processes. Among these proteins, SAA1 was found to be significantly upregulated, showing functional enrichment in acute inflammatory pathways. Further investigation at both animal and cellular levels reve

SUBMITTER: Zhu P 

PROVIDER: S-EPMC12722397 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature