Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes.

ABSTRACT:

Introduction

Macrophages comprise a significant portion of the glioblastoma tumor microenvironment and are essential in promoting immunosuppression and tumor progression. Solid tumors such as glioblastoma generate solid stress as they expand, creating a compressive microenvironment for mechanosensitive immune cells including macrophages. Macrophages are known to respond to various mechanical stimuli but have not yet been studied in the context of chronic compression observed in growing tumors.

Methods

Here, we used a custom in vitro compression system to elucidate the effects of compressive solid stress on murine macrophages.

Results

We found that macrophages have significant morphological, transcriptional, metabolic, and functional responses to compression. Th

SUBMITTER: Burchett Darantiere A 

PROVIDER: S-EPMC12722438 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature