Proteomic Profiles of Neutrophils from Behcet's Uveitis Patients and their Sex Differences.

ABSTRACT: Behcet's uveitis (BU) is one of the most vision-threatening uveitis entities with male-biased incidence and severity. Neutrophil dysfunction has been implicated in the pathogenesis of this disease. However, their proteomic changes are not completely understood. We performed proteomic analysis on peripheral neutrophils from patients with active BU and identified 82 up-regulated and 516 down-regulated differentially expressed proteins (DEPs) compared to healthy controls (HCs). We further performed functional analysis on these DEPs and found that the pathway involved in neutrophil extracellular trap formation was activated, whereas nucleotide metabolism and apoptosis were suppressed. Compared with female patients, male patients presented enhanced pathways associated neutrophil-mediated inflam

SUBMITTER: Liu R 

PROVIDER: S-EPMC12722440 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature