Cross-talk between aging resilience pathways and autoimmunity onset.

ABSTRACT: Aging and autoimmunity intersect through the progressive decline of resilience pathways that maintain physiological stability. Resilience refers to the integrated capacity of molecular, cellular, and systemic mechanisms to repair damage, adapt to stress, and preserve immune tolerance. With advancing age, resilience deteriorates due to chronic inflammation, cellular senescence, epigenetic drift, and metabolic dysfunction. While a wide spectrum of autoimmune diseases exists, this perspective focuses primarily on those that emerge or progress with advancing age, in which a decline in immune resilience rather than congenital immune defects plays the predominant role. These changes weaken adaptive capacity and promote conditions that allow autoreactive lymphocytes to persist, initiating autoimm

SUBMITTER: Mittal R 

PROVIDER: S-EPMC12722448 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature