Hepatoid adenocarcinoma of the stomach and non-hepatoid alpha-fetoprotein-producing gastric cancer exhibit a high degree of molecular similarity.

ABSTRACT:

Background

There is currently no unified consensus on the diagnosis and treatment of hepatoid adenocarcinoma of the stomach (HAS) and non-hepatoid AFP-producing gastric cancer (AFPGC). This study aims to explore the molecular similarities between the two, providing a basis for the diagnosis and precision treatment of these patients.

Methods

We retrospectively collected tumor tissues, adjacent tissues, and peripheral blood samples from 83 patients for whole-exome sequencing or transcriptome sequencing. Spearman correlation analysis, unsupervised clustering analysis and so on were performed to assess the similarity between different sample groups, explore the molecular features of non-hepatoid AFPGC and HAS, and compare their correlations.

Results

All the patient groups

SUBMITTER: Chen L 

PROVIDER: S-EPMC12722461 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature