Genetic Insights in Hindbrain Abnormalities Through Network Analysis Expose Key Biological Pathways in Hindbrain Development.

ABSTRACT: The number of known developmental disorders affecting the hindbrain is rapidly increasing due to advances in neuroimaging and genetic technologies. Nevertheless, it remains largely unknown why the development of the hindbrain is affected in many genetic disorders. We aim to unveil new insights into the biological pathways essential for hindbrain development by investigation of the pathogenetics of hindbrain abnormalities. In this work, an updated gene list of abnormalities of the hindbrain was generated, and genes were subsequently grouped according to most prevalent association in (1) predominantly cerebellar, (2) cerebellar and brainstem and (3) brainstem malformations. Brain-specific gene co-expression networks were generated to identify functional relationships and novel genes that wer

SUBMITTER: van Noort SAM 

PROVIDER: S-EPMC12722476 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature